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If your opponent is playing a fast deck, it makes sense to remove some of your expensive card advantage or slow top end cards for a mediocre two drop or cheap play that can help you stabilize

A particularly interesting application of this would be to cast a Surgical Extraction effect on your own Slime Against Humanity, letting you search your own deck for any number of copies and exiling them

After all, not only are these cards the most expensive on TCGplayer, but theyre also absolutely gorgeous

Pirate Ship can't attack unless defending player controls an Island

Alternatively, it lets you build up ten counters total to deal ten damage to any target, a line which, in most cases, will likely translate to your opponent. The Sylex starts to shine when you consider its nuances, however

If both packets are aggro-oriented or control-oriented, they'll mix well