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Developer: Eli Lilly and Company | Administration in Trials: Once-weekly subcutaneous injection First successful Phase 3 trial (TRIUMPH-4, topline Dec 2025): Up to 28.7% average body weight loss at 68 weeks (highest dose) in adults with obesity/overweight and knee osteoarthritis

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investigated infertile PCOS patients with obesity randomly assigned to metformin 1000 mg BID or to metformin 1000 mg BID combined with low-dose liraglutide 1.2 mg/day for 12 week, and demonstrated that weight, BMI, and WC decreased with both treatments, without significant difference between the two arms [59]