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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Presented for research literature review only Martos-Maldonado MC et al

Instructions At the beginning of the treatment, 1 ampoule with 1 mlvitamin B 12 Lichtenstein (corresponding to 1000 micrograms of cyanocobalamin) is added twice a week in the first weeks after diagnosis

Possible clinical applications are women with central obesity, HIV-associated lipodystrophy, or metabolic syndrome in which visceral fat negatively affects reproductive outcomes

Handling Protocol: Avoid repeated freezethaw cycles after preparation

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