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van Dooren FE, Nefs G, Schram MT, Verhey FR, Denollet J, Pouwer F

In the heart, the metabolome is characterized by amino acid depletion, evidence of altered redox balance including glutathione depletion, and a shift from oxidative phosphorylation to alternative energy production pathways

At 6 months, weight reduction averaged 5%, with semaglutide, liraglutide, and exenatide showing comparable effects, while lean mass remained largely preserved

GLP-1s may offer a dual benefit for patients with chronic conditions like diabetes or obesity who are also struggling with a substance use disorder: one medication can treat both conditions at once, Al-Aly said

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The resulting holoenzyme dimer comprising the two subunits is catalytically more efficient and less subject to inhibition by GSH than GCLC alone