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Ongoing months: monthly billing, medication shipment, periodic clinical check-ins (every 4 to 12 weeks depending on program), titration adjustments as appropriate

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Understanding the dose-response relationship is essential for designing appropriate research protocols [9]

It is characterized by progressive biliary inflammation and fibrosis, often leading to cirrhosis, portal hypertension, and liver failure, with liver transplantation remaining the only life-prolonging treatment for advanced cases 59,60

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