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Also, high-dose B12 has been linked to acneiform eruptions in some case reports and reviews (Bahbouhi et al., 2023) as described in the PubMed record

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Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work

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It is to note that the treatment regime of vitamin B12 (frequency and daily dose) the oral and IM groups varied in these studies

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