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Less common but more serious risks include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), kidney injury (with severe dehydration), and retinopathy worsening in patients with pre-existing diabetic retinopathy

If you've been on stable thyroid medication for at least 6-8 weeks and levels are in a reasonable range, adding semaglutide is appropriate

doi: 10.3390/molecules25245789 82 PalleriaCLeporiniCMaidaFSuccurroEDe SarroGArturiFet al

Short- and medium-term use is well-tolerated under medical guidance

Safety is strong, although they should be paused before procedures with bleeding risk

Injectables In a seminal March 2021 New England Journal of Medicine study, adults receiving a weekly 2.4 mg injection of semaglutide for about 15 months lost 15% of their body weight 35 pounds, on average