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232,233 In addition to the inactivating mutation of Wnt/-catenin pathway components, abnormal secretion of Wnt ligands in many tumours can also lead to overactivation of the Wnt/-catenin pathway (DKK1, Wnt3a, and Wnt5a)
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There are no completed human clinical trials, and this material is supplied strictly as a laboratory research reagent
Calculating units for any dose at any concentration uses one formula: Units = (desired dose in mg / concentration in mg per mL) x 100 For example, at 2.5 mg/mL concentration, a 0.375mg dose would be: (0.375 / 2.5) x 100 = 15 units
doi: 10.1038/nrneph.2012.61 30 SisBHalloranPF
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