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[1] A second large randomized trial of similar design (404 patients, with a 6-month efficacy phase and a 6-month extension) reproduced the effect, and patients who continued tesamorelin to 12 months showed a sustained VAT reduction of roughly 18%

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(4)(5) Opioid receptors : Further research indicates that DSIP might indirectly affect opioid receptors in the brain

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