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BMJ Meta-Analysis (2014): Among 353,639 patients, pooled odds ratios showed no excess risk of pancreatitis for either GLP-1 agonists or DPP-4 inhibitors
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Technical challenges are still high with the efforts to achieve acceptable bioavailability of dual peptide combinations when administered orally, but if achieved, it could greatly increase the patient population that can be addressed by oral therapy, since the psychological barrier that exists with the use of injectable therapy are being responsible for eliminating a large number of patients who are eligible to use oral therapy
C.OlivierB.WaldingerM
