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While not appropriate for acute severe pain requiring immediate analgesia, peptides may reduce chronic pain by addressing underlying pathology that perpetuates pain signaling

However, these findings are not yet backed by large human trials

A 2025 systematic review found: After analyzing 985 resultant articles and 5 records identified outside of the databases through citation tracking, 10 studies that met the inclusion criteria were included in the systematic review

What we care about most, though, are interventional studies, where people are randomized to B12 so we can see what happens

This is after its chief, David Kenley, admitted several months ago that there is no proof it had any body-enhancing effects in humans

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