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Tirzepatide can cause mild gastrointestinal discomfort, including nausea, vomiting, and constipation, particularly during the initial stages of treatment

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Consistent with the pharmacological results, the above results provide convincing evidence that the GPX4 overexpression protects TECs from ferroptosis and mitigates renal interstitial fibrosis

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Data were pooled using random-effects models with subgroup analyses by drug type and treatment duration (3, 6, and 12 months)