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48,49 Heart Rate Increase GLP-1RAs are known to cause a modest, dose-dependent increase in resting heart rate

The existing methods for phenotypic selection of genetically modified mammalian cells are mainly based on three types of phenotypic markers: an exogenous drug resistance gene that permits screening for positive cells, a fluorescent protein, such as GFP, that allows isolating positive cells by FACS (fluorescence-activated cell sorting) (Chen et al., 1999), or a membrane protein that enables antibody-based immunomagnetic selection of positive cells (Plouffe et al., 2015)

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Whilst off-label prescribing is sometimes appropriate in clinical practice when supported by evidence and clinical judgement, it carries specific responsibilities and risks that both prescribers and patients must carefully consider

Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches