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Fifth, the duration of follow-up was limited to 12 months, which may not be sufficient to capture longer-term outcomes, delayed effects, or the durability of observed associations over time

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Secondary endpoints were changes in the Hepatic Encephalopathy Scoring Algorithm (HESA), venous ammonia, and tolerability

Falta de respuesta adecuada : Si despus de 3-6 meses de tratamiento a la dosis teraputica completa no se observan mejoras significativas en el control glucmico (reduccin de HbA1c de al menos 0.5-1%) o en el peso corporal (prdida de al menos 5% del peso inicial cuando se prescribe para manejo de peso), debe consultar con su mdico