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Store lyophilised vials at -20C, protected from light and moisture

Contact your GP or prescribing clinician if you experience: Severe or persistent abdominal pain , particularly if sharp, localised, or worsening, which could indicate pancreatitis or other serious conditions Sudden or persistent right upper abdominal pain, fever, jaundice, pale stools or dark urine which may indicate gallbladder disease (cholelithiasis or cholecystitis) Persistent vomiting that prevents adequate fluid or medication intake, risking dehydration Signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst, which may lead to acute kidney injury in at-risk patients Blood in stools (either bright red or dark, tarry stools) or persistent rectal bleeding Severe diarrhoea lasting more than 48 hours or accompanied by fever Unexplained weight loss beyond expected therapeutic effects or loss of appetite that seems excessive New or significantly worsened symptoms in patients with pre-existing IBS or inflammatory bowel disease Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, unrelenting abdominal pain, especially if radiating to the back Persistent vomiting with inability to keep down fluids Signs of severe dehydration or altered consciousness Symptoms suggestive of bowel obstruction (severe bloating, inability to pass stool or wind, vomiting) For patients with pre-existing gastrointestinal conditions , including diagnosed IBS, Crohn's disease, ulcerative colitis, or gastroparesis, closer monitoring is advisable when starting Wegovy

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Skin, Hair, and Nail Changes GLP-1 medications can cause changes in the skin and hair

Diabetologia (2016) 59(5):105969