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Samples were split for baseline and GCL activity measurements

Metformin primarily addresses insulin resistance and hepatic glucose production, whilst semaglutide enhances insulin secretion, reduces appetite, and slows gastric emptying

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All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation

Moore-Morris, T

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