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Whilst there is no established direct mechanism by which GLP-1 receptor agonists consistently cause joint pain, several indirect factors may explain why some patients experience musculoskeletal discomfort during treatment

This manifests as an increased general ROS amount, severely depleted intracellular GSH pools, and oxidation of redox sensitive proteins including the T H 17-regulating transcription factor STAT3

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GridleyDSSlaterJMLuo-OwenXRizviAChapesSKStodieckLSet alspaceflight effects on T lymphocyte distribution, function and gene expression