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An alternative and more quantitative approach would be to directly measure PV/BV using the indicator-dilution method, but that would not be practical in a large-scale, international, multicenter randomized trial, leaving us no viable alternatives to explore this potential mechanism

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Taken together, it has been proposed that muscle loss during GLP-1 RAs-based therapy is largely adaptive and proportional to overall weight reduction, and that improvements in muscle quality and insulin sensitivity may help offset potential functional decline [97]