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GIP plays a role in: Fat metabolism Insulin sensitivity Energy utilization By engaging both pathways, tirzepatide influences appetite, blood sugar regulation, and metabolic signaling more broadly

For instance, the effects of GLP-1 on food intake and glucose homeostasis are, at least in part, neurally mediated (78, 79), and co-release of GLP-1 and ATP from neuropod cells has been shown to elicit a vagal response (80)

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Elevated homocysteine is associated with various diseases, such as heart and brain diseases

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In a comprehensive meta-analysis including 76 RCT and more than 39 thousand participants with type 2 diabetes, treatment with GLP1RAs was associated with a reduction in HbA1c of -0.6% to -2.1% as well as reduction of -10.8 to -57.7 mg/dl in the fasting blood glucose levels relative to placebo [14]