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Because these medications are both GLP-1 RAs, they have similar side effects
Rotate injection sites within the same area to reduce the risk of lipodystrophy
Although few animal studies reported an improvement in indices of fibrosis or prevention of the initiation of fibrosis [8, 26, 29], most studies do not support a robust effect of GLP-1RAs on hepatic fibrosis (Table 1)
Type 1 diabetes GLP-1 RA starts are currently off license and do blend better with individual consultations rather than a group setting at this time
Tirzepatide weight loss outcomes also depend on comprehensive care, including lifestyle supportnot just medication alone
TRIUMPH-4 showed retatrutide achieving 28.7% weight loss at 68 weeks in December 2025
