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This gradual escalation allows the gastrointestinal system to adapt and typically produces better tolerability than jumping directly to higher doses
PMID: 21039821 Garca-Arns JA, et al
Insoluble fiber nudges stool along your digestive tract, speeding transit
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Sharma RB, ODonnell AC, Stamateris RE et al (2015) Insulin demand regulates cell number via the unfolded protein response
This presents a problem, since while 0.1% TFA is required for superior peak shape and optimum retention, it also causes ion suppression, resulting in a weaker MS signal
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