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Aquaporin-8 (AQP8) facilitates H 2 O 2 diffusion in GI ( 2 O 2 membrane permeability and signaling, making it an essential player in redox signaling processes ( 2 O 2 transport through the plasma membrane, influencing redox signaling pathways associated with leukemia cell proliferation ( 3.2 RNS in IBD pathogenesis RNS comprise the second category of free radicals, produced as a byproduct of nitric oxide synthases(NOS) and expressed in specific intestinal submucosa and mucosal regions

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In conclusion, GPLC appears to be a useful dietary supplement to enhance anaerobic work capacity and potentially sport performance, but apparently the dosage must be determined specific to the intensity and duration of exercise