From a pharmacological perspective, there is no official contraindication to combining Wegovy with a ketogenic diet according to the MHRA-approved Summary of Product Characteristics (SmPC)
For example, manufacturer Novo Nordisks titration protocol for weekly Wegovy injections looks like: Weeks 1-4: 0.25mg Weeks 5-8: 0.5mg Weeks 9-12: 1mg Weeks 13-16: 1.7mg Week 17+: 2.4mg Despite this gradual increase, youre most likely to experience pronounced side effects early in semaglutide treatment as your body adjusts to the medication
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doi: 10.1021/acs.jmedchem.7b00174 79 NestorJJZhangXJaw-TsaiSParkesDGBeckerCK
Primary pathological features include hepatic fat accumulation, inflammation, fibrosis, and ballooning degeneration of hepatocytes
Xue M, Chen X, Guo Z, Liu X, Bi Y, Yin J, et al