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Tretinoin (0.05%) : A powerful derivative of Vitamin A that promotes cell turnover, reduces the appearance of fine lines, and enhances skin texture

This acidifies the tissue microenvironment, which can suppress T cell function and cytotoxicity, further impairing the antiviral immune response (65)

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There is also a potentially relevant interaction between VEGF and FGF-2, as synergistic action between these two factors has been reported in the literature

10.1161/01.atv.20.9.2094 Arterioscler Thromb Vasc Biol