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There is no universal answer, which is why a real clinical decision starts with a real conversation

If metformin doesnt work well enough on its own, a GLP-1 RA is often added to the treatment plan

| Int J Cardiol

Because of the way it works, it's only FDA-approved for people with certain genetic conditions, namely: Proopiomelanocortin (POMC) deficiency, Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, Leptin receptor (LEPR) deficiency, and Bardet-Biedl syndrome (BBS)

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