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The absence of GEP44-mediated changes to the ISR in the absence of a Y1-R antagonist suggests two possible mechanisms that would be consistent with the serum glucose-lowering effects observed in response to this chimeric peptide in vivo

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Functions through direct binding to PPARd ligand-binding domain, modulating gene transcription via PPAR response elements (PPREs)

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One of the most common uses of glutathione for skin is as a lightening agent