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There is a preferential transport of GSSG from the cytosol to the endoplasmic reticulum to maintain an adequate environment for protein disulfide bond formation and protein folding ( Glutathione and the -glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called -glutamyl cycle (Figure 5) ( - glutamyl cycle was postulated by Meister (Figure 5)

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Phase 1 reaction is thought to prepare a drug for phase 2

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