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AHA for sensitive skin stands for alpha-hydroxy acids, and they're basically your skin's gentle nudge to get its act together

To view a copy of this licence, visit About this article Cite this article Samkari, J

Other groups that are at a greater threat of having a vitamin B12 deficiency consist of cigarette smokers (given that nicotine could obstruct absorption), alcoholics, those with anemia, and any individual with a gastrointestinal condition like Celiac or Crohns illness

W., Fam, B., Summers, R., Conway-Campbell, B., Waters, M

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

Tafuri A, DeFelica L, Petrucci MT, Valentini T, Meloni G, Goodacre AM, Amadori S, Andreeff M , Mandelli F