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While the serum concentration of cobalamin is used diagnostically, the reactions catalyzed by cobalamin dependent enzymes occur in the mitochondria, making it difficult to assess the state of cobalamin availability in the patient
Available from: Tracey ML, Li-Fen L, Cindy L, Shen L, John M, Homero R, et al
Healthcare providers can offer better treatments for diabetic neuropathy with high-dose B12 therapy
"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature
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With aging, muscle stem cell function gradually declines, showing reduced proliferation and fusion, leading to impaired regeneration-one of the key mechanisms underlying sarcopenia.In vitro experiments confirm that 5-amino-1mq significantly enhances the proliferation and fusion of muscle stem cells from aged mice
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