Naturally means something different to each person
In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months
This means that it mimics the hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), both of which naturally regulate appetite and insulin
How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test reveals your predispositions in key GLP-1 pathway variantsGIPR rs1800437, FTO rs9939609, and MC4R rs17782313so you can understand whether your genetics suggest you are likely a strong responder to natural GLP-1 stimulation or whether your biology may benefit from additional medical support
The good news is that our bodies usually produce it
What happened in the rodent studies In two-year toxicology studies, rats receiving tirzepatide developed dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumors, including both adenomas and carcinomas