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The kidney also rapidly filters small peptides (under ~6 kDa)
Optimizing dietary habits while on GLP-1 therapy enhances both medication efficacy and tolerability
What Are the Side Effects and Risks of GLP-1 Medication
Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)
Many patients successfully manage constipation through consistent hydration, adequate fiber, and regular movement without needing medication
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