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The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 5 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies

J Med Chem 44:42684276

25 Vitamin C at 2 grams daily supported healthy blood histamine levels by 38% in studies

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Beyond weight loss, GLP-1 analogues have other health benefits