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Unlike, say, salicylic acid, its primary function in skin doesn't involve exfoliation
Cell Transpl
These drugs are used to treat diabetes and are classified as GLP-1 RAs (receptor agonists), also known as agonists GLP-1 RAS or peptide 1 receptor agonists
Another sulfur-containing compound, shikonin ( Figure 7 ), appears to have anticancer properties via suppressing the migration, adhesion, viability, and invasion of gastric (MGC-803) and hepatocellular (Huh7and BEL7402) cancer cells in vitro via the TLR2/NF-B and receptor-interacting protein 1 (RIP1)/NF-B pathways (284, 285)
However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention
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