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Male BALB/c-nu nude mice aged 4 weeks and weighing 18 ~ 22 g were purchased from the Experimental Animal Centre of Southern Medical University (Guangzhou, China) and housed in a specific pathogen-free air-conditioned room (25 2 and 65% 5% humidity) with a 12-h light/dark cycle

Kang T, Boland BB, Jensen P, Alarcon C, Nawrocki A, Grimsby JS, et al

Clinical trials have shown that oral semaglutide can support weight loss in adults with overweight or obesity

The primary role of 5-Amino-1MQ is to disable the "metabolic brake" known as NNMT

Interestingly, studies have shown that the antioxidant activity of this compound has a circadian rhythm, having antioxidant properties when it is in the dark but pro-oxidant properties when it is in the light (Zhou et al., 2021)