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An event can be severe but not serious, for example, a severe headache

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37 Additionally, a meta-analysis published in Gastroenterology concluded that split-dose regimens are more effective than day-before preparations, with 4-L split-dose PEG showing particularly high efficacy

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In contrast, FBXO7 knockdown significantly increases the synthesis of serine and glycine and promotes the proliferation of hepatocellular carcinoma xenografts ( Hyperactivation of the SSP increases the supply of substrates for m6A methylation, further sustaining the high expression of PCK2 and NRF2, ultimately resulting in significantly reduced sensitivity of hepatocellular carcinoma cells to lenvatinib ( 4.1.5 Glioblastoma In glioblastoma (GBM), especially within the serine/glycine (S/G)-deprived brain microenvironment, the SSP is significantly activated ( In terms of expression synergy, the concurrent high expression of all three key enzymes indicates that the SSP is fully activated in these cancer types