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Another reason some patients ask is confusion about how GLP-1 works, sometimes mistaking these medications for insulin, which is dosed multiple times daily based on meal timing and blood glucose levels

N Engl J Med 2016 Nov 10

Some people notice appetite suppression within the first few days or weeks of starting tirzepatide, while others experience more gradual changes as dosage increases

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At ACR Convergence 2025, researchers from Toronto and NYU reported that PsA patients starting GLP-1 receptor agonists had significant improvements in joint counts, CRP, pain scores, and DAPSA disease activity scores within one year of treatment. Whats interesting is that you dont seem to need a large dose to see these benefits