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Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

Hankosky ER, Wang H, Neff LM, Kan H, Wang F, Ahmad NN, et al

Reactivity and ionization of the active site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo

In leaky gut syndrome, erosion of the mucous layer occurs, followed by a breakdown of the tight junctions

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