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10.1016/j.joca.2020.06.005 65
Some users have reported side effects online, including anxiety, fatigue, mood changes, and heart problems
GlutathioneSide Effects
The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking
Stopping rules: Discontinue GHK-Cu if free copper exceeds 25 mcg/dL, 24-hour urine copper exceeds 100 mcg/day, ALT or AST rises to more than 3 times the patient's baseline value, or clinical signs of copper toxicity appear
DPP-4 inhibitors can also be used in dual therapy or in triple therapy with metformin when blood glucose is not adequately controlled to individualised targets
