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1 Detailed pre-specified analysis from a sub study of SYNCHRONIZE-1 show that, relative to baseline, survodutide achieved a reduction of up to 34% in visceral fat, with the proportion of lean mass loss reflecting no more than 10.8% of change in total tissue mass at the highest dose, alongside an up to 63.1% reduction of liver fat, indicating a targeted reduction in metabolically harmful fat after 76 weeks

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Its function in the regulation different cell death pathways has attracted particular attention

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Therefore, many studies have focused their attention on the search of substances that could restrain this increase in exercise-induced oxidative stress

The AT lab is funded by grants from Diabetes UK (19/0006094), the MRC (MR/X021467/1), and the Wellcome Trust (301619/Z/23/Z)