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We propose an important contribution of de novo ser/gly synthesis pathway activation to RT responses by supplying ATP, nucleotides, and antioxidants to support the survival and/or recovery of cancer cells upon RT

MPO and hypochlorous acid (HOCl) expression were significantly upregulated in NSC-34 cells transfected with the human SOD1 G93A gene, leading to the activation of the MPO/HOCl signaling pathway

Moreover, in both infected and mock-infected cells treated with inhibitor, levels of NRF2 and G6PD proteins ( Figure 6B ), as well as intracellular GSH/GSSG ratio ( Figure 6C ), increased in comparison to untreated cells

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2004 Jul;11 Suppl 1:S73-85