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Formal rulemaking may take time Adding a substance to the final 503A Bulks List generally involves notice-and-comment rulemaking

GLP-1 analogues are often prescribed for chronic conditions such as type 2 diabetes and obesity, which require ongoing, long-term management

Competing interests Outside of this work, the authors disclose the following relationships: SF: payments to the institution (Canadian Institutes of Health Research, National Institute of Health, Medtronic, Boston Scientific, Amgen), participation on advisory board (PolyPid)

Conclusion GLP-1 receptor agonists have emerged as powerful agents that improve metabolic health lowering blood sugar, inducing weight loss, and reducing cardiovascular risk in patients with diabetes or obesity

However, signaling through both the GLP-1R and the GCGR have been shown to enhance GSIS